Sydney Morning Herald – 2014

Anyone who watches regular television would be hard-pressed to avoid cosmetic company ads claiming to unlock the secret to eternal youth.

These advertisers are highly adept to preying on people’s insecurities about ageing, yet in the main there is little scientific basis for their claims.

In June L’Oreal USA was forced to settle charges of deceptive advertising about its Lancome Genifique and L’Oreal Paris Youth Code skincare products. According to the US Federal Trade Commission’s complaint, L’Oreal products falsely claimed to be providing anti-ageing benefits by targeting users’ genes.

In and among all this an Aussie firm has been paving the way towards understanding how genes can be understood to improve skin care. Specialising in collecting a person’s individual genetic fingerprint, SkinDNA claims it is leading the world in analysing skin ageing and other skin problems.

The company says it can analyse a particular person’s susceptibility to sun damage and propensity to wrinkling, putting a scientific perspective on what has long been an entirely subjective beauty application.

Founder Stefan Mazy, 27, began work at the tender age of 19 in a cosmetic clinic. It’s probably the only glass ceiling for a male, he says, but it was not his gender which altered his career path, but a glaring gap in the market.

“Nobody were I worked could explain to me why some ingredients were better than others. Why was layering important? For me it was all about the whys. All they said was that the collagen breakdown was all in the genes. So I said, what’s in the genes?”

Mazy’s ardent curiosity led him on a one-man beauty crusade. Convinced Australia was too small, he set up SkinDNA, found the right people to help him to create a test kit and analysis reports and took his concept to America. Through his US distributor he managed to spruik his concept on several television shows including CBS’s The Doctors and Good Morning America. “We’re still waiting for the call from Dr Oz, although we did make it into his magazine,” Mazy laughs.

SkinDNA sells the test kit to distributors, who then sell it down the line to cosmetic clinics and eventually to the end customer. A swab is taken of the saliva in a customer’s mouth which is then sent back to the SkinDNA lab to create an individual skincare profile.

Mazy’s company, of which he owns 70 percent, is highly feted: SkinDNA was a finalist in the 2013 NSW Export Awards, in the healthcare and biotechnology category. The company now has 400 clinics offering his testing kit and analyses across Australia.

Mazy says a typical treatment will usually be ongoing from three to six months, depending on each person’s specific needs and age. The cost of initial testing varies from $299 to $499. Interestingly, he says Aussies tend to suffer more skin damage from their diet than from the sun. “We are a sunburnt country but our problem is glycation – excess sugar.”

Excess sugar will bind to the collagen, causing it to go brittle and develop crevasses. Other problems relate to an excess of a protein known as MMP1 which leads to a decline in the skin’s health and appearance, leading to wrinkles, roughness and sagging.

Mazy has been approached by several big cosmetic companies to acquire his data. SkinDNA has collected more than 15,000 DNA samples from various ethnic groups, all of which would be of interest to cosmetics firms. “Proctor and Gamble have requested our information twice,” Mazy says. “L’Oreal has three brands interested in partnering with us for a total solution package.”

All the same, Mazy realises this kind of intellectual property requires scale to be effectective. “Skincare companies would kill to have it. Imagine – that amount of DNA date of our customers,” Mazy says.

“That’s where the value will be. But it’s not big enough yet. When it is, we will list the company.”

MiNDFOOD – 2017

Elsewhere, beauty brands are combining a multitude of protective elements in order to defend and repair the skin from damage.

“Even with the best sunscreen products, some of the damaging UV rays will sneak through” advises Angela Frazer, plastic surgical and cosmetic nurse for Prescription Skin Care. “Using an antioxidant serum such as vitamin C will act as a second line of defence, picking up where your sunscreen leaves off [while] stimulating collagen production and lightening pigmentation.” Frazer advises layer antioxidants under a mineral make-up with broad spectrum UVA and UVB protection.

At Clinique, the current focus exciting researchers is infrared radiation (IR), which was previously thought to have a benign effect on the body. Recent research by a team from Seoul National University Hospital demonstrated IR adds to premature skin ageing. “What is exciting in the suncare research area is the news that IR and pollution is damaging to skin,” says Dr Tom Mammone, executive director of Skin Physiology and Pharmacology at Clinique Research & Development, Worldwide. “The future of protecting skin from suncare includes protection from IR and pollution. We are working on making our products not just stronger against these damaging environmental insults but also making them last longer.” When it comes to repair, the world’s leading dermatologists agree that a combination of antioxidants and peptides are needed to mend any sun damage that occurs despite using sunscreen.

“For repair, the technologies for the next 20 years are going to be extremely potent and will rival dermatologists in their efficacies. We are already making products that compete with prescription treatments and lasers. Our next wave of products will surpass them,” says Cliniques Dr Mammone. SkinDNA’s Stefan Mazy, points to the study of biomimcry, where science imitates beauty phenomena. “What stops plants from burning or shrivelling up during the long summer days? Scientists [are studying] these specimens and isolating the exact chemicals produced by the plant.” Two of Mazy’s suncare ingredients are resveratrol, which is released in some plants after sun exposure to repair UV damage, and kojic acid – which is used by plants to prevent browning, and can help reduce pigmentation in human skin.

Similarly, American skincare brand DNA EGF’s Intensive Renewal is a product that contains an enzyme derived from one of the most UV-resistant organisms known to science, according to Kim Larsen, national sales manager at House of Camille, supplies of salon brand including DNA EGF. Larsen says the enzyme, found in soil and the ocean, stimulates the recognition and elimination of damage to the skin, to reverse sun damage (dnaegfrenewal.com). Increasingly, genetics is being incorporated into the industry’s approach to skincare and protection. “Our genetic predispositions play an important role in determining how well your skin can naturally cope under the strains of the sun,” says SkinDNA’s Mazy. “The SkinDNA Genetic Test can help to identify many underlying issues that cause pigmentation and skin damage before the signs become apparent.”

TAILORED CARE

SkinDNA’s test kits involve taking a swab from inside your mouth and sending it to the company for analysis (available at inskincosmedics.com.au). The results can help uses to tailor their sun protection and care to their own genetic risk factors. “We know that two in five people have a genetic impairment affecting their body’s UV-protecting ability,” says Mazy.

“Genetic variations can lower your body’s ability to produce melanin, [causing] the skin to be highly sensitive when exposed to sunlight.” Such knowledge is seeing products customised to the individual and their personal needs, with the addition of specific sunscreens, peptides, antioxidants and photo protectants tailored to the user’s needs. Genetics will have an increasing role in the coming decade, as scientists isolate the individual genes involved in pigmentation and sun protection.

Researchers at Harvard University Massachusetts General Hospital Department of Dermatology have been studying the possibility of stimulating skin pigmentation with a molecule rather than UV radiation, as a way of naturally boosting the skin’s melanin levels from within. The resulting “safe tan” would provide fairer skins with a more naturally protected state.

Good Housekeeping – 2017

Your friend raves about a moisturiser but, even though you have the same skin type, it does nothing for you? It may be time to consult your genes…

Since 2012, beauty brand Olay has been collaborating with genetics company 23andMe to investigate the genes linked to skin ageing and understand how they vary according to ethnicity. Led by a Harvard professor of dermatology, the study examined approximately 20,000 genes and identified that ‘exceptional skin ages’, those people who appear almost ageless, have a unique skin ‘fingerprint’ of around 2,000 genes. Decoding these could hold the keys to looking youthful for longer.
In the meantime, there’s a small but growing number of companies in the UK offering the ultimate in personalised skincare – a regime based on genetic tests. The latest service, FutureSkin DNA (£495, katekerrlondon.co.uk), comes from holistic facialist Kate Kerr at London’s Phi Clinic, and may just be the best skincare consultation I’ve ever had.

Kate begins by taking a DNA swab from the inside of your mouth. This goes off to an Australia company that looks at 16 genetic markers related to skin ageing and compares your results with its database of over 40,000 people. Kate also gives you a mini exploratory facial, asking endless questions about your skin and then yet more questions via an in-depth questionnaire that also goes off to Australia.

Two weeks later, you back to learn you genetic predisposition to collagen breakdown (think firmness and elasticity), sun damage and pigmentation, free radical damage, inflammation and sensitivity, and glycation (excess sugars link to skin’s collagen and elastin fibres, reducing their regenerative ability and, in the long term, causing deep wrinkles). Specific skincare, ingredients and supplements are identified that will work well with your ene profile, which Kate explains thoroughly. Armed with this information, you can buy tailored beauty products from her or simply read labels when you go shopping – and of course, re-assess your current skincare routine and any products you already have at home. Kate also gives plenty of lifestyle advice and tips, as healthy habits can override your genetic results – just as bad habits can eventually get the better of in-built genetic protection. Although I found I had plenty to thank Mum and Dad for, I do have a high risk of glycation. One solution? Eat less cake!

Sydney Morning Herald – 2016

Technology is offering tailor-made solutions for managing our skin, and its ageing process, better than ever before, writes Katrina Lawrence

With the spring 2015 haute couture collections kicking off today in Paris, the made-to-measure chich is in the spotlight. Ready-to-wear brands Burberry and Prada personalise some offerings, with monogramming and customisation services. But it’s in the skincare industry where personalisation is picking up a serious buzz.

The human genome was mapped back in 2003, but the implications for how we manage our skin’s aging process are becoming clearer, as more research is undertaken into the various skin genes. “The possibilities are limitless,” says Stefan Mazy, founder of SkinDNA, an Australian skin genetic testing service. “The personal genomics industry is still in infant stage because it’s not just about taking a test, it’s about understanding the information behind what the markers are all about.”

SkinDNA involves a cheek swab for a saliva sample, along with a questionnaire covering lifestyle factors. From here, the SkinDNA laboratory looks at 16 markers – or DNA sequences – within five categories; firmness, glycation, sun damage, free radical damage and sensitivity. A skin therapist utilises this report to design a treatment program focussing on the categories in which a patient is medium or high risk, and the most suitable active ingredients. “We’re always adding new markers to the test to understand more about the skin,” Mazy says. An expanding database also means SkinDNA is able to conduct correlate studies and accumulate more data, and a greater understanding of the skin’s ageing.

“It took the guesswork out for our O Cosmedic salons,” says Marie Enna-Cocciolone, CEO of Inskin Cosmedics, distributor of SkinDNA and several cosmeceutical brands.

“We now know which products and dosage are required to preserve skin.”
Facialists who in conjunction with a SkinDNA report have a clearer idea of where younger clients’ skin is heading, for mature clients, it allows therapists to focus on the most effective treatments.

“Some people think sugar they eat is contributing to their skin concerns, but then find their glycation levels are low,” Enna-Cocciolone says.
“However, if the high-risk is in collagen breakdown, you’d prescribe a program focussed on collagen synthesis.”

A personalised guide to skin ageing also allows the consumer to shop smarter. “We’re overwhelmed with so much choice that we can make poor decisions,” says Mazy. “With DNA testing, we can recommend ingredients to the products that will be best for them.”

For Singapore brand Skin Inc, available at Sephora Sydney, personalised skincare comes in the form of My Daily Dose, a set of three encapsulated serums that are custom-mixed at home in a dedicated bottle; the trio of active ingredients is prescribed based on a questionnaire, and are ideally taken every three months.

“In life, we customise a lot,” says Sabrina Tan, founder and CEO of Skin Inc.
“Every morning we choose a different outfit and make-up palette. But what changes the most? The skin. So it’s important to customise skincare. This is not a trend. It’s a fact.”

DNA Magazine – 2013

Wrinkling, sagging skin, sun damage.
What new skincare technology rarely interests me – but the SkinDNA Genetic Test got me excited! DNA Magazine interviews Stefan Mazy from SkinDNA

Will: New skincare technology rarely excites me but Skin DNA got me tingling. Tell me more about it.

Stefan Mazy:
Imagine if you can use brand name skincare products specifically suited to your genetic make-up, or undergo skin treatments that will actually work for your skin. Imagine if you could predict how your skin would age? This may all sound like science fiction, but it’s now possible. Skin DNA is… well, a DNA test for skin.

Skin DNA is tailored to helping men and women find out what exactly is the best thing for their skin. It’s a simple at-home saliva swab test that analyses your skin’s genetic make- up and, using science, can accurately predict whether wrinkles, sun damage, pigmentation, firmness or elasticity will be the biggest problems as time goes by.

With the results comes the knowledge to apply the right skincare regime and products. It’s very common that people are using the wrong skincare. There are advantages to knowing what skincare to use. When people know what might happen to them in the future, they would be more aware about what kind of treatments they should be doing to their skin now.

Will: You checked my DNA. What did you discover? Was I immaculately conceived and born in a manger as my mother suggests, or is it just skin stuff you analyse?

Stefan Mazy:
Sorry mister, no magic tricks here. We’re all about science, the good, the bad and the ugly. Your results revealed that you were:
High Risk for a process called Glycation – unprocessed sugar binds to collagen fibers causing them to break creating wrinkles. My advice to is hit the gym, incorporate blueberry extract and green tea extract into your skincare and lower your sugar intake.
Medium Risk for sun damage and pigmentation – in particular how well you can tan (melanin production). This crucial component is what protects you from the sun (fake tan doesn’t count). Tanning issues can leave you very prone to pigmentation, wrinkling and accelerated skin aging, as well as a few other nasties like cancer. My advice: photo protectant ingredients like vitamin C and zinc in your skincare program. Lycopene and green tea extract as supplements and sun exposure for 10 minutes twice a week between 11am and 2pm to help get your body used to producing melanin.
Medium Risk for loss of firmness and elasticity – basically your body is breaking down collagen faster than it can produce it which means overtime gravity will become one of your nightmares; much sooner than other people. My advice is use retinol, CoQ10 and some peptides in your skincare. Also include Soy in your diet and LED treatments once a week.

Will: Look into your crystal ball. At what age will Will Fennell officially look old?

Stefan Mazy:
In my eyes you’ll be young forever Will, however, according to the data if you don’t do anything expect to see a speedy decline in the next two years. (At this point I put down my pen and contemplated stabbing him with it).

Will: For the non-believers out there, convince them.

Stefan Mazy:
The science is there. The proof is there and a 50 billion dollar industry can’t be wrong. If everyone were the same, there wouldn’t be so many skincare choices. Just like knowing your genetic risk in developing Alzheimer’s disease or lung cancer in the medical world and doing what you can to minimize the risk, Skin DNA is designed as a solution to better tailor particular aging traits before they become apparent.

It’s just like saying, do you start to go to the gym when you become obese and depressed or do you go to prevent this from happening in the first place? Better yet, what is going to be cheaper, preventing or fixing? Skin DNA is being used to advance beyond the one-size-fits-all suggestions. Gone are the days where we say, “eat an apple a day” or “just wear sunscreen and you’ll be fine”.

Searching for the best beauty products doesn’t come cheaply, but now a simple genetic test could be the secret to maintaining a youthful glow.

Australian Advanced Aesthetics – 2010

Born to be Beautiful? GENOMICS INSIGHTS INTO HEALTHY SKIN

SkinDNA ™ revolutionizes the cosmetic industry with its genetic test to assess an individual’s DNA; revealing their genetic propensity to intrinsic skin aging.

Imagine if you can recommend a skincare product specifically suited to your client’s genetic make-up, or perform skin treatments using parameters determined by their DNA. Sounds like something from science fiction, but thanks to recent research in genomics that may not be too far in the future.

Today the field of cosmetic medicine is on the brink of a scientific revolution; thanks to recent advancements in field of Personal Genomics it’s now become possible to purchase a genetic test that will assess an individual’s DNA to reveal their genetic propensity to intrinsic ageing. This information can be used to empower individuals to make health-promoting lifestyle and dietary changes, and help skin professionals make more informed treatment choices.

The practise of cosmetic medicine has been marked by several great technological innovations in the last century. The 1958 invention of Laser optics in the field of physics for example, eventually transformed the face of cosmetic medicine. The use of Botulinum Toxin in Ophthalmology first in the 1960’s – little would we have known at the time – would go on to become a standard worldwide treatment for dynamic facial wrinkles. Like most innovations, each of these occurred in external scientific disciplines which eventually transferred into ours. This technological diffusion process, this time from the field of Personal Genomics, is yet again set to change the face cosmetic medicine.

Genetic testing use to be limited to the realms of forensic analysis and parental identity, but with the unravelling of the complete human genome in 2003 it’s been a lot more pervasive. In 2008 the winner of Time Magazine’s invention of the year wasn’t NASA’s Lunar Reconnaissance Orbiter, the Tesla Roadster (an all-electric sports car made by Tesla Motors), nor was it the Large Hadron Collider particle accelerator. It was a new Personal Genetics test being offered by 23andMe. It represented the true beginning of a personal genomics era, with several companies following suit.

In the Genes

In 1909, Danish botanist Wilhelm Johanssen coined the word ‘gene’ for the hereditary unit found on a chromosome. Nearly 50 years earlier, Gregor Mendel had characterised hereditary units as ‘factors’, or observable differences that were passed on from parent to child. Today, we know that a single gene consists of a unique sequence of DNA that provides the complete set of instructions to make a protein. Genes instruct cells to make sets of proteins at just the right times, and it is through this specificity that our ‘uniqueness’ arises.

The concept of uniqueness is important because even though the DNA of any two individuals is more than 99.9% identical, every one of us (except for identical twins) is genetically unique. The crucial difference lies in the remaining 0.1% – differences most typically represented as variations known as Single Nucleotide Polymorphism (or SNPs). Genomics research has determined that many SNPs can be associated with an increased risk of disease including Breast Cancer, Prostate Cancer, Parkinson’s disease, Melanoma and Diabetes – to name a few. But the influences of SNP’s don’t stop with disease; they determine most of our personal characteristics – everything from the colour of our hair to the shape of our nose, to the thickness of our hair and as recently discovered, the youth and vitality of our skin.

The Quest for Youth

Our discipline has long been focused on the maintenance of youth, or at least of a youthful-looking skin. This has important utility for our patients, because a youthful-looking skin is significant in interpersonal contact and in personal satisfaction. Recognising this we’ve made extensive efforts into researching and documenting the age-related changes of the skin: thinning, exaggerated expression lines, enlarged pores, wrinkling, pigmented lesions, patchy hypopigmentations, and actinic keratosis. What’s been missing is a proper understanding of the intrinsic molecular mechanisms involved

Answers from the human genome

That is where recent findings from the global SkinDNA™ research collaboration led by Australian pharmacogenomics company Wellbeing Genomics Pty Ltd comes in. The collaboration of geneticists, cosmetic physicians, skin scientists, and volunteer study participants commenced their work in 2006 with two principle objectives in mind: (1) To identify the genetic factors that contribute to age-related changes in the skin; and (2) to identify “actionable pathways” available for each of those genetic pathways in order to “help each and every individual worldwide preserve a more youthful-looking skin”.

The researchers profiled the action of 6,347 genes and – using genome-wide association studies – they discovered more than 200 abnormal gene traits in the form of Single Nucleotide Polymorphisms (SNPs) implicated in the health and wellbeing of our skin. Most significant was the prevalence of some of these SNP’s and the effect they had on the skin. Whilst many of these findings are due to be outlined in a forthcoming paper, we can reveal some of the results:

30% of the adult population were found to have a specific 2G2G polymorphism in the Matrix Metalloproteinase-1 gene increasing their predisposition to excessive collagen breakdown;
Polymorphisms in the ERC22 gene having a population prevalence of 27% was associated with increased sensitivity to sunlight and heightened sunlight-induced skin damage.

The 5 cellular ageing processes

The genes tested were catalogued according to the structural, functional and metabolic effects they had on the skin. Together with the knowledge of the molecular events that underlie the ageing process, the researchers were able to identify five cellular processes involved in skin ageing. These can be described broadly as: Collagen Breakdown, Photo Defense, Oxidation, Inflammation and Glycation – each one of which is controlled by a specific group of genes. A Polymorphism in any one of these genes changes its molecular activity and intervenes with the skin’s normal ageing process.

1. Collagen Breakdown

Collagen is an important element of human skin; in fact it is the principle structural protein holding skin together. Representing 75% of the skin’s dry weight, the quantity and quality of Collagen plays a major role in the skin’s appearance. The genes in this category are involved in slowing the breakdown and degradation of Collagen Fibers found in the extracellular matrix of human tissue. Key variations in our genes can identify if the synthesis and degradation process of Collagen inclined to be in balance, or if the predisposition to collagen degradation predominates – which can result in premature sagging and wrinkling of the skin.

2. Photo Defence

Causing premature skin aging and a host of other profound changes to the skin, repeated exposure to ultraviolet light (UV radiation) from the sun accounts for nearly 90% of symptoms of premature skin aging, skin damage and skin cancer. Genetics were shown to play an important role in determining how well our skin can naturally cope under the strains of the sun.

3. Oxidation

The Oxidation process starts with Free Radicals. Free radicals are highly reactive short lived molecules that can damage virtually any molecule in our body – including the important cellular structures found in the body’s largest organ – the skin. This kind of free radical damage leads to the generation of even more free radicals! It’s a chain reaction that can wreak havoc in every layer of the skin – including the Hypodermis, Dermis and the particularly vulnerable epidermis. This sort of cellular destruction in any one of the skin’s layers can lead to a dull, lifeless, aged complexion. It’s not all bad news however, because our bodies have been built with a natural defence: Internal Antioxidants. The activity of these internal antioxidants is determined in large part by their mediating genes, and their activity levels were found to vary substantially.

4. Inflammation

Inflammation is the skin’s first line of defense against foreign invaders such as bacteria and viruses. Inflammation also initiates the tissues healing processes and limits the damage to skin cells caused by everyday chemicals and pollutants. Excessive inflammation is one of the most common themes in early onset skin aging. While it is a helpful response in the short term, if inflammation continues on-going, it can play a very harmful role. Often subtle, the signs include skin sensitivity, redness and irritation.

5. Glycation

Glycation causes the skin proteins (like collagen and elastin) to lose their ability to function normally; Glycation is now well recognised and heavily implicated in accelerated skin aging. Advanced Glycation End Products (A.G.Es) are the end result of a glucose-driven process known as Glycation. Glycation occurs when excess bodily glucose molecules link to the skin’s Collagen and Elastin fibers. This cross-linking can form chemical bridges between these proteins. Glycated fibres can become rigid, less elastic and have reduced regenerative ability, which can lead to damage such as laxity, cracking and thinning skin.

Current and future implications

The implications of these findings are vast. Not only has the SkinDNA™ allowed physicians and skin professionals to incorporate a cutting-edge genomics test into the care of its patients, it has also provided the tools to pave the way for new strategies for diagnosis, treatment and prevention plans. As the skin’s ageing mechanisms are further identified, and further insights into the underlying processes of skin ageing emerge, better strategies to prevent the undesirable effects of skin ageing should follow. In the near future, look out for new gene and cell therapies to repair skin damage and to optimise skin health as well as personalised skincare and skin treatment programs tailored to an our very own DNA
By R.G.

SkinDNA ™ is being used to analyse your skin’s genetic makeup and predict the biggest problems as time goes by.

Cosmetex 2014

The Australasian College of Cosmetic Surgery (ACCS)
Welcome Cosmetex 2014 – the Asia-Pacific’s largest and most significant meeting devoted to Cosmetic Medical Practice..

SKIN AGING IS IN THE GENES – Abstract
S. MAZY^1
1 International Education Department, SkinDNA, Sydney, AUSTRALIA

Introduction

Imagine if you can recommend skincare products specifically suited to your client’s genetic make-up, or perform skin treatments using parameters determined by their DNA. It may sound like something from science fiction, but thanks to recent research in genomics it’s now become a reality.

Today, the field of cosmetic dermatology is on the brink of a scientific revolution. Thanks to recent advancements in the field of personal genomics, it has now become possible to take a genetic test to assess an individuals DNA; revealing their genetic propensity to intrinsic skin aging. This information can be used to empower individuals to make health-promoting lifestyle and dietary changes, and help skin professionals make more informed treatment choices.

Methods

The company privately profiled the action of 6,347 genes and – using genome wide association studies – they discovered more than 200 abnormal gene traits in the form of Single Nucleotide Polymorphisms (SNPs) implicated in the health and wellbeing skin.

Results

Most significant was the prevalence of some of the SNPs and the effect they had on the skin. Some f the findings include – thirty percent of the population were found to have a specific 2G2G polymorphism in the Matrix Metalloprotease one Gene – increasing their predisposition to increased collagen breakdown;

Polymorphisms in the ERC22 genes which having a population prevalence of 27 per cent, was associated with increased sensitivity to sunlight and heightened sunlight induced skin damage

Conclusion

The implications of these findings are vast. Not only have these findings allowed physicians and skin professionals to incorporate a cutting-edge genomics test into the care of its patients, it has also provided the tools to pave the way for new strategies for diagnosis, treatment and prevention plans. As the skin’s aging mechanisms are further identified, and further insights into the underlying processes of skin aging emerge, better strategies to prevent the undesirable effects if skin aging will change the way we care for our skin. SkinDNA is leading the way.

Stefan Mazy presenting in the Science Program,

Both SkinDNA Genetic Test and our White Label SkinShift partner featured on CBS News

CBS News 2016