Glucose is the sugar your body uses as its main source of fuel. If not metabolized properly, glucose can bind to your skin’s collagen and elastin fibers, forming abnormal chemical bridges that cause tissue damage. This process, called glycation, causes your skin to become rigid and lose elasticity.
Glycation also impairs your skin’s ability to regenerate, which leads to skin laxity, cracking, thinning, redness, and inability to self-repair.
The genes that make up your Wrinkling (A.G.E.) score play a key role in skin Glycation. They are responsible for controlling serum glucose levels, energy intake and energy release.
Having variations in these genes can alter the functioning of normal glucose levels and energy metabolism. While glucose is a vital cellular fuel, if not completely metabolised by the body Glycation can occur, leading way to wrinkling, dryness and laxity.
SkinDNA™ Designated Descriptors
Responsible for controlling serum glucose levels, energy intake and release. While glucose is a vital cellular fuel, if not fully metabolised Glycation can occur.
Advanced Glycation End Products (A.G.Es) are the end result of a glucose-driven process known as Glycation. Glycation occurs when excess bodily glucose molecules link to the skin’s Collagen and Elastin fibers. This cross-linking can form chemical bridges between these proteins. Glycated fibers can become rigid, less elastic and have reduced regenerative ability, which can lead to damage such as laxity, cracking and thinning skin.
In young skin, the Dermal Epidermal Junction has the appearance of a mountain range that helps anchor the Epidermis to the Dermis, forming a network of supportive Collagen fibers.
As your skin ages these supportive fibers—which are responsible for the appearance and texture of your skin—lose their supportive network as a result of glycation.
Our genetic predispositions play a big role in determining serum glucose levels. Key variations in this genetic category play a key role in preventing glycation of your skin.
It is responsible for controlling serum glucose levels, energy intake, and energy release. Having variations in this gene can alter your body’s ability to maintain normal glucose levels and interfere with energy metabolism, both of which lead to glycation.
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Collagen is just one of thousands of different proteins in the body. The most abundant protein is collagen. In fact, collagen makes up more than one third of all protein in the body and about 75% of the skin.
Enough elastin in the skin means that the skin will return to its normal shape after a pull or a pinch. It also helps keep skin smooth as it stretches to accommodate normal activities like flexing a muscle or opening and closing the mouth to talk or eat.
But glucose has its dark side. If not properly metabolised Glucose can bind tightly to proteins and form abnormal chemical bridges that progressively damage tissue elasticity. This process is referred to as Glycation.
This cross-linking can form chemical bridges between these proteins. Glycated fibers can become rigid, less elastic and have reduced regenerative ability, which can lead to damage such as laxity, cracking and thinning skin.